Looking for sex in salt Augusta

Added: Shuan Fichter - Date: 29.01.2022 20:16 - Views: 16629 - Clicks: 8242

Obesity and a high-salt diet are both bad for our hearts but they are bigger, seemingly synergistic risks for females, scientists report. Belin de Chantemele, whose research team has been exploring why so many young women are now getting cardiovascular disease, is presenting their findings during the Henry Pickering Bowditch Award Lectureship at the American Physiological Society Annual Meeting at Experimental Biology this week.

The sex hormone estrogen, which has some protective powers like keeping Looking for sex in salt Augusta vessels more flexible, is considered a natural protection for premenopausal women yet, along with soaring rates of severe obesity in young women, heart disease is now the third leading cause of death in females between the ages — fourth for males in that age group — then moves up to second place for the next 20 years in both sexes, and is the one killer for both men and women looking at all ages, according to the National Vital Statistics Reports.

Belin de Chantemele has shown that in females leptin prompts the adrenal glands, which make aldosterone, to make even more of this powerful blood vessel constrictor. Like leptin, females, regardless of their weight, already have naturally higher levels of aldosterone and actually bigger adrenal glands as well. A result: Obesity actually produces larger blood pressure increases in females, and studies indicate that females also are more prone to obesity associated vascular dysfunction — things like more rigid blood vessels that are not as adept as dilating.

On the other hand, leptin actually increases production of the vasodilator nitric oxide — which reduces blood pressure — in the male mice, one of many cardiovascular differences they are finding between males and females. Increased salt intake should suppress aldosterone, and it does work that way in males, Belin de Chantemele says. But in females it appears to set them up for more trouble. Aldosterone is the main mineralocorticoid, a class of hormones that helps maintain salt balance, and Belin de Chantemele and his team reported in in the journal Hypertension that the hormone progesterone, which enables pregnancy, also enables high levels of these mineralocorticoid receptors for aldosterone in the endothelial cells that line blood vessels in both female lab animals and human blood vessels.

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When they deleted either the mineralocorticoid or progesterone receptor in the females, it prevented the blood vessel dysfunction that typically follows, and just knocking out the progesterone receptor also suppressed the aldosterone receptor. The bottom line is that progesterone is key to the sex difference in aldosterone receptor expression on endothelial cells, which predisposes females to obesity associated, high-leptin driven endothelial dysfunction and likely high blood pressure, Belin de Chantemele says.

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They reported a few years before in the same journal that higher leptin levels produced by more fat prompts the adrenal glands to make more aldosterone in females. High sodium intake is known to raise blood pressure, by increasing fluid retention, and both pre- and postmenopausal females are more salt sensitive than males, Black females even more so, he says.

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Treatment with the aldosterone agonist eplerenone helped correct both. Because females already make more aldosterone, and the normal response of the body when you eat a lot of salt is to make even more aldosterone to help eliminate some of it, his team now proposes that females appear to have an impaired ability to reduce both the levels of the enzyme that makes aldosterone and the hormone itself, which makes them more salt sensitive.

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It also means that they think that blood vessels are more important in blood pressure regulation in females than males, which means they may need different treatment than males. While trends in being overweight in about the last 50 years have held pretty steady for men and women, with decreases for men in the last handful of years, rates of severe obesity have been climbing, with women far outpacing men. His research team includes Galina Antonova, research assistant; Dr.

Jessica Faulkner, postdoctoral fellow. Contact her to schedule an interview on this topic or with one of our experts at or tbaker augusta. Daily updates highlight the many ways students, faculty, staff, researchers and clinicians "bring their A games" in classrooms and clinics on four campuses in Augusta and locations across the state of Georgia. Have something to brag about? Jagwire wants to hear about it. Augusta University. Search Search.

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Toni Baker 5 min read April 29, Eric Belin de Chantemele. Written by. Related articles. Jul Copper transporter potential new treatment target for cardiovascular disease Toni Baker. Written by Toni Baker.

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Looking for sex in salt Augusta

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Female Sex, a Major Risk Factor for Salt-Sensitive Hypertension